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Magnetic field responsive methylcellulose polycaprolactone nanocomposite gels for targeted and controlled release of 5-Fluorouracil.
Department of Chemistry, Faculty of Engineering, Istanbul University, Avcilar, Istanbul, Turkey.
Department of Chemistry, Faculty of Engineering, Istanbul University, Avcilar, Istanbul, Turkey.
Number of Authors: 2
2016 (English)In: International Journal of Polymeric Materials, ISSN 0091-4037, E-ISSN 1563-535X, Vol. 65, no 8, 421-432 p.Article in journal (Refereed) Published
Abstract [en]

5-Fluorouracil loaded magnetic field sensitive methylcellulose and polycaprolactone gels were prepared and characterized by FTIR, XRD, TGA, SEM, and VSM. Swelling analysis supplied important information on drug diffusion properties. The release profile of gels was investigated in different buffer solutions and the highest release values were observed at pH¼7.2. Release kinetic was analyzed using an empirical equation to clarify the transport properties of drug. The effects of nanoparticle concentration and applying external magnetic field were investigated on release profile. The results indicated that the drug release decreased by both, applying external magnetic field and increasing the concentration of Fe3O4nanoparticles.

Place, publisher, year, edition, pages
2016. Vol. 65, no 8, 421-432 p.
National Category
Other Materials Engineering
Research subject
Engineering Materials
Identifiers
URN: urn:nbn:se:ltu:diva-61902DOI: 10.1080/00914037.2015.1129954OAI: oai:DiVA.org:ltu-61902DiVA: diva2:1073173
Available from: 2017-02-09 Created: 2017-02-09 Last updated: 2017-03-16Bibliographically approved

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