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Pharmaceutical Crystal Engineering Using Ionic Liquid Anion–Solute Interactions
Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Chemical Engineering.
Luleå University of Technology, Department of Health Sciences, Medical Science.
Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Chemical Engineering.
Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Chemical Engineering.
Number of Authors: 4
2017 (English)In: Crystal Growth & Design, ISSN 1528-7483, E-ISSN 1528-7505Article in journal (Refereed) Epub ahead of print
Abstract [en]

The main purpose of this work was to investigate the potential of ionic liquids (ILs) in crystal engineering. We have employed ILs with different combinations of cations and anions to study their role in directing crystal structure formation of a nicotinamide (NIC) and oxalic acid (OXA) system. A new crystal form of NIC–OXA salt (2:1) was identified and characterized using standard solid state tools such as powder X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, and Raman and infrared spectroscopy. The crystal structure of the 2:1 salt was elucidated using single-crystal X-ray diffraction. The NIC–OXA 2:1 salt form revealed a two-dimensional layered structure, while the known 1:1 salt had a perpendicular “tape-like” structure. The 2:1 salt form could only be crystallized from the ILs possessing hydrogen bond acceptor functionality. We demonstrated that specific ILs could be selected as solvents for altering the solid-state structure of organic and inorganic materials.

Place, publisher, year, edition, pages
2017.
National Category
Physical Chemistry Other Health Sciences
Research subject
Chemistry of Interfaces; Health Science
Identifiers
URN: urn:nbn:se:ltu:diva-62372DOI: 10.1021/acs.cgd.6b01698OAI: oai:DiVA.org:ltu-62372DiVA: diva2:1079887
Available from: 2017-03-09 Created: 2017-03-09 Last updated: 2017-03-15

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Publisher's full texthttp://pubs.acs.org/doi/abs/10.1021/acs.cgd.6b01698

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Shimpi, ManishkumarVelaga, SitaramShah, Faiz UllahAntzutkin, Oleg
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CiteExportLink to record
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