Selective N-alkylation of primary amines with R-NH2·HBr and alkyl bromides using a competitive deprotonation/protonation strategy
Number of Authors: 5
2014 (English)In: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 4, no 35, 18229-18233 p.Article in journal (Refereed) Published
Monoalkylation of primary amines using amine hydrobromides and alkyl bromides has been carried out. Under controlled reaction conditions the reactant primary amine was selectively deprotonated and made available for reaction, while the newly generated secondary amine remained protonated, and did not participate in alkylation further. Reaction was carried out under mild reaction conditions and was applicable to a wide range of primary amines and alkyl bromides.
Place, publisher, year, edition, pages
2014. Vol. 4, no 35, 18229-18233 p.
Research subject Chemistry of Interfaces
IdentifiersURN: urn:nbn:se:ltu:diva-62811DOI: 10.1039/c4ra01915fOAI: oai:DiVA.org:ltu-62811DiVA: diva2:1085859