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Porous hydroxyapatite scaffolds fabricated from nano-sized powder via honeycomb extrusion
Luleå University of Technology, Department of Health Sciences, Medical Science. (Pharmaceutical and Biomaterials Lab)ORCID iD: 0000-0003-1304-3686
2017 (English)In: Advanced Materials Letters, ISSN 0976-3961, E-ISSN 0976-397XArticle in journal (Refereed) In press
Abstract [en]

In this study, we have developed hydroxyapatite (HA) scaffolds for synthetic bone graft from nano-sized HA particles using ceramic extrusion. We also demonstrate that these HA scaffolds show enhanced compressive strength (29.4 MPa), whilst possessing large pore sizes (> 600 µm) that are suitable for bone grafting. The extrusion process involved forming a ceramic paste by mixing the HA powder with a binder and distilled water. The ceramic paste was then fabricated using a ram extruder that was fitted with a honeycomb die to impart large, structured pores. Several green bodies were extruded and then subjected to the same drying and thermal debinding treatment. The samples underwent three different sintering temperatures and two varied dwell times, in order to determine the optimum sintering parameters. The scaffolds were then analysed for their chemical, physical, mechanical and biological properties to elucidate the effects of the sintering parameters on extruded HA scaffolds. The results revealed that the nano-sized particles exhibited a high sinterability, and XRD analysis showed phase purity until 1300 oC. At 1300 oC, trace amounts of phase impurities were detected, however, scaffolds sintered at this temperature exhibited the highest mean compressive strength. The findings demonstrated that traces of phase impurities were not detrimental to the scaffold’s compressive strength. In addition, scanning electron microscopy and density measurements revealed a highly densified solid phase was attained.

Place, publisher, year, edition, pages
2017.
National Category
Other Health Sciences
Research subject
Health Science
Identifiers
URN: urn:nbn:se:ltu:diva-63157DOI: 10.5185/amlett.2016.7063OAI: oai:DiVA.org:ltu-63157DiVA: diva2:1091299
Available from: 2017-04-26 Created: 2017-04-26 Last updated: 2017-05-10

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CiteExportLink to record
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Citation style
  • apa
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