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Berberine: A potential phytochemical with multispectrum therapeutic activities
Luleå University of Technology, Department of Health Sciences, Medical Science. Banaras Hindu University, Institute of Technology, Department of Pharmaceutics, Varanasi .
Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi .
Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanasi, Uttar Pradesh.
2010 (English)In: Expert Opinion on Investigational Drugs, ISSN 1354-3784, E-ISSN 1744-7658, Vol. 19, no 10, 1297-1307 p.Article in journal (Refereed) Published
Abstract [en]

Importance of the field: The use of traditional medicines of natural origin is being encouraged for the treatment of chronic disorders, as synthetic drugs in such cases may cause unpredictable adverse effects. Berberine, a traditional plant alkaloid, is used in Ayurvedic and Chinese medicine for its antimicrobial and antiprotozoal properties. Interestingly, current clinical research on berberine has revealed its various pharmacological properties and multi-spectrum therapeutic applications. Areas covered in this review: An extensive search in three electronic databases (Unbound Medline, PubMed and ScienceDirect) and internet search engines (Scirus and Google Scholar) were used to identify the clinical studies on berberine, without any time constraints. This review elaborates the recent studies which reveal that with time, the drug has evolved with superior therapeutic activities. In addition, this review will also attract the attention of formulation scientists towards the issues and challenges associated in its drug delivery and the probable approaches that may be explored to help patients reap the maximum benefit of this potentially useful drug. What the reader will gain: A relatively large number of studies discussed here have revealed the possible areas where this phytochemical constituent can exhibit its therapeutic activities in the treatment of chronic ailments or diseases including diabetes, cancer, depression, hypertension and hypercholesterolemia. Take home message: The potential of the drug remains to be harvested by designing a suitable formulation that could overcome its inherent low bioavailability

Place, publisher, year, edition, pages
2010. Vol. 19, no 10, 1297-1307 p.
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Other Health Sciences
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Health Science
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URN: urn:nbn:se:ltu:diva-63461DOI: 10.1517/13543784.2010.517745PubMedID: 20836620Scopus ID: 2-s2.0-77956589652OAI: oai:DiVA.org:ltu-63461DiVA: diva2:1096855
Available from: 2017-05-19 Created: 2017-05-19 Last updated: 2017-11-24Bibliographically approved

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Rao Vuddanda, Parameswara

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