Francis turbines are often operated over a wide load range due to high flexibility in electricity demand and penetration of other renewable energies. This has raised significant concerns about the existing designing criteria. Hydraulic turbines are not designed to withstand large dynamic pressure loadings on the stationary and rotating parts during such conditions. Previous investigations on transient operating conditions of turbine were mainly focused on the pressure fluctuations due to the rotor-stator interaction. This study characterizes the synchronous and asynchronous pressure and velocity fluctuations due to rotor-stator interaction and rotating vortex rope during load variation, i.e. best efficiency point to part load and vice versa. The measurements were performed on the Francis-99 test case. The repeatability of the measurements was estimated by providing similar movement to guide vanes twenty times for both load rejection and load acceptance operations. Synchronized two dimensional particle image velocimetry and pressure measurements were performed to investigate the dominant frequencies of fluctuations, vortex rope formation, and modes (rotating and plunging) of the rotating vortex rope. The time of appearance and disappearance of rotating and plunging modes of vortex rope was investigated simultaneously in the pressure and velocity data. The asynchronous mode was observed to dominate over the synchronous mode in both velocity and pressure measurements.