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Films loaded with insulin-coated nanoparticles (ICNP) as potential platforms for peptide buccal delivery
Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile, Santiago .ORCID iD: 0000-0002-3190-2168
College of Pharmacy, The University of Texas at Austin, Austin, TX .
College of Pharmacy, The University of Texas at Austin, Austin, TX.
cCollege of Pharmacy, University of New Mexico, Albuquerque, NM .
2014 (English)In: Colloids and Surfaces B: Biointerfaces, ISSN 0927-7765, E-ISSN 1873-4367, Vol. 122, 38-45 p.Article in journal (Refereed) Published
Abstract [en]

The goal of this investigation was to develop films containing insulin-coated nanoparticles and evaluate their performance in vitro as potential peptide delivery systems. To incorporate insulin into the films, a new antisolvent co-precipitation fabrication process was adapted to obtain insulin-coated nanoparticles (ICNPs). The ICNPs were embedded in polymeric films containing a cationic polymethacrylate derivative (ERL) or a combination of ERL with hydroxypropyl methylcellulose (HPMC). ICNP-loaded films were characterized for morphology, mucoadhesion, and insulin release. Furthermore, in vitro insulin permeation was evaluated using a cultured tridimensional human buccal mucosa model. The antisolvent co-precipitation method was successfully adapted to obtain ICNPs with 40% (w/w) insulin load, achieving 323±8nm particles with a high zeta potential of 32.4±0.8mV, indicating good stability. High yields were obtained after manufacture and the insulin content did not decrease after one month storage. ICNP-embedded films using ERL as the polymer matrix presented excellent mucoadhesive and insulin release properties. A high permeation enhancement effect was observed for ICNP-loaded ERL films in comparison with ICNP-loaded ERL-HPMC films and a control insulin solution. ICNP-loaded ERL formulations were found to be more effective in terms of film performance and insulin permeation through the human buccal mucosa model, and thus are a promising delivery system for buccal administration of a peptide such as insulin.

Place, publisher, year, edition, pages
2014. Vol. 122, 38-45 p.
Keyword [en]
Buccal delivery, Insulin-coated nanoparticles, Permeation enhancement, Protein and peptide delivery
National Category
Pharmaceutical Sciences Other Health Sciences
Research subject
Health Science
Identifiers
URN: urn:nbn:se:ltu:diva-64676DOI: 10.1016/j.colsurfb.2014.05.025PubMedID: 25016543Scopus ID: 2-s2.0-84904358029OAI: oai:DiVA.org:ltu-64676DiVA: diva2:1118590
Available from: 2017-06-30 Created: 2017-06-30 Last updated: 2017-11-24Bibliographically approved

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Morales, Javier O.

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