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Potential use of nanocarriers with pentacyclic triterpenes in cancer treatments
Departamento de Ciencias y Tecnología Farmacéutica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago.
Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo.
Departamento de Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago.
2016 (English)In: Nanomedicine, ISSN 1743-5889, E-ISSN 1748-6963, Vol. 12, no 23, 3139-3156 p.Article in journal (Refereed) Published
Abstract [en]

Ursolic, oleanolic and betulinic acids are representative pentacyclic triterpenoids found in various plants and fruits. Despite having marked antitumor potentials, the very poor water solubility of these triterpenes hinders treatment development. Nanotechnology can enhance solubility, stability, bioavailability and phytochemical delivery, improving the therapeutic efficiency of triterpenes. This review focuses on the formulation, characterization and in vitro/in vivo evaluation of several delivery nanosystems used to enhance the physicochemical properties of ursolic, oleanolic and betulinic acids

Place, publisher, year, edition, pages
2016. Vol. 12, no 23, 3139-3156 p.
National Category
Other Health Sciences
Research subject
Health Science
Identifiers
URN: urn:nbn:se:ltu:diva-64737DOI: 10.2217/nnm-2016-0251Scopus ID: 2-s2.0-84999266459OAI: oai:DiVA.org:ltu-64737DiVA: diva2:1118941
Available from: 2017-07-03 Created: 2017-07-03 Last updated: 2017-07-03Bibliographically approved

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