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Novel strategies for the buccal delivery of macromolecules
Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile.ORCID iD: 0000-0002-3190-2168
College of Pharmacy, University of New Mexico, Albuquerque, NM.
2014 (English)In: Drug Development and Industrial Pharmacy, ISSN 0363-9045, E-ISSN 1520-5762, Vol. 40, no 5, 579-590 p.Article in journal (Refereed) Published
Abstract [en]

For years now, the delivery of small molecules through the buccal mucosal route has been described in the literature, but it has only been over the past decade that investigations into macromolecule delivery via the buccal route have sharply increased. The administration of macromolecules such as proteins and peptides, antibodies, or nucleic acids by buccal administration would be greatly enhanced due to the avoidance of the gastrointestinal conditions, rapid uptake into systemic circulation, as well as the potential for controlled drug delivery. Since macromolecules are faced with a number of specific challenges related to permeation through the epithelium, several strategies have been employed historically to improve their buccal absorption and subsequent bioavailability. Several conventional strategies to improve macromolecule penetration include the use of chemical permeation enhancers, enzyme inhibitors and the use of mucoadhesive materials acting as carriers. More recent approaches include the incorporation of the macromolecule as part of nanostructured delivery systems to further enhance targeting and delivery. This review focuses on the different permeation enhancing strategies as well as formulation design that are tailored to meet the challenges of active macromolecule delivery using the buccal mucosal route of administration.

Place, publisher, year, edition, pages
2014. Vol. 40, no 5, 579-590 p.
National Category
Pharmaceutical Sciences Other Health Sciences
Research subject
Health Science
Identifiers
URN: urn:nbn:se:ltu:diva-64674DOI: 10.3109/03639045.2014.892960PubMedID: 24611816Scopus ID: 2-s2.0-84898606498OAI: oai:DiVA.org:ltu-64674DiVA: diva2:1119615
Available from: 2017-07-04 Created: 2017-07-04 Last updated: 2017-11-24Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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  • modern-language-association-8th-edition
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Output format
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