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Buccal delivery of small molecules and biologics: of mucoadhesive polymers, films, and nanoparticles
Luleå University of Technology, Department of Health Sciences, Medical Science.ORCID iD: 0000-0002-3190-2168
UCD School of Veterinary Medicine and UCD Conway Institute, University College Dublin.
2017 (English)In: Current opinion in pharmacology (Print), ISSN 1471-4892, E-ISSN 1471-4973, Vol. 36, 22-28 p.Article in journal (Refereed) Published
Abstract [en]

Buccal delivery of macromolecules (biologics) sets a great challenge for researchers. Although several niche small molecule products have been approved as simple sprays, tablets and oral films, it is not simply a case of adapting existing technologies to biologics. Buccal delivery of insulin has reached clinical trials with two approaches: oromucosal sprays of the peptide with permeation enhancers, and embedded gold nanoparticles in a dissolvable film. However, neither of these approaches have led to FDA approvals likely due to poor efficacy, submaximal peptide loading in the dosage form, and to wide intra-subject variability in pharmacokinetics and pharmacodynamics. It is likely however that printed film designs with lower molecular weight stable biotech payloads including lipophilic glucagon-like 1 (GLP-1) agonists and macrocycles with long half-lives will generate greater efficacy than was achieved to date for insulin.

Place, publisher, year, edition, pages
Elsevier, 2017. Vol. 36, 22-28 p.
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Other Health Sciences
Research subject
Health Science
Identifiers
URN: urn:nbn:se:ltu:diva-65107DOI: 10.1016/j.coph.2017.07.011PubMedID: 28800417Scopus ID: 2-s2.0-85026830309OAI: oai:DiVA.org:ltu-65107DiVA: diva2:1133383
Note

Validerad; 2017; Nivå 2; 2017-08-15 (andbra)

Available from: 2017-08-15 Created: 2017-08-15 Last updated: 2017-11-24Bibliographically approved

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