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Buccal delivery of small molecules and biologics: of mucoadhesive polymers, films, and nanoparticles
Luleå University of Technology, Department of Health Sciences, Medical Science. Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile, Santiago .ORCID iD: 0000-0002-3190-2168
UCD School of Veterinary Medicine and UCD Conway Institute, University College Dublin.
2017 (English)In: Current opinion in pharmacology (Print), ISSN 1471-4892, E-ISSN 1471-4973, Vol. 36, p. 22-28Article in journal (Refereed) Published
Abstract [en]

Buccal delivery of macromolecules (biologics) sets a great challenge for researchers. Although several niche small molecule products have been approved as simple sprays, tablets and oral films, it is not simply a case of adapting existing technologies to biologics. Buccal delivery of insulin has reached clinical trials with two approaches: oromucosal sprays of the peptide with permeation enhancers, and embedded gold nanoparticles in a dissolvable film. However, neither of these approaches have led to FDA approvals likely due to poor efficacy, submaximal peptide loading in the dosage form, and to wide intra-subject variability in pharmacokinetics and pharmacodynamics. It is likely however that printed film designs with lower molecular weight stable biotech payloads including lipophilic glucagon-like 1 (GLP-1) agonists and macrocycles with long half-lives will generate greater efficacy than was achieved to date for insulin.

Place, publisher, year, edition, pages
Elsevier, 2017. Vol. 36, p. 22-28
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Other Health Sciences
Research subject
Health Science
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URN: urn:nbn:se:ltu:diva-65107DOI: 10.1016/j.coph.2017.07.011ISI: 000419665100006PubMedID: 28800417Scopus ID: 2-s2.0-85026830309OAI: oai:DiVA.org:ltu-65107DiVA, id: diva2:1133383
Note

Validerad; 2017; Nivå 2; 2017-08-15 (andbra)

Available from: 2017-08-15 Created: 2017-08-15 Last updated: 2018-07-10Bibliographically approved

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Morales, Javier O.

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