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Effect of surfactants and drug load on physico-mechanical and dissolution properties of nanocrystalline tadalafil-loaded oral films
Luleå University of Technology, Department of Health Sciences, Medical Science.
Department of Pharmaceutical Sciences and Technology, University of Chile.
Luleå University of Technology, Department of Health Sciences, Medical Science.
Luleå University of Technology, Department of Health Sciences, Medical Science.ORCID iD: 0000-0002-0654-5410
2017 (English)In: European Journal of Pharmaceutical Sciences, ISSN 0928-0987, E-ISSN 1879-0720, Vol. 109, 372-380 p.Article in journal (Refereed) Published
Abstract [en]

The aim of the present work was to prepare tadalafil (TDF) nanocrystals-loaded oral polymeric films (OFs) and investigate the effect of hydrophilic surfactants and drug loads on the physico-mechanical and dissolution properties. The nanosuspensions of TDF were prepared by high shear homogenization. HPMC based placebo casting film gel was prepared and mixed with TDF nanosuspensions. Films were casted using an automated film applicator and dried at 60 °C for 45 min. Particle size (PS), polydispersity index (PDI), and zeta potential (ZP) of TDF nanosuspensions were measured in a Zetasizer. The films were characterized using SEM, AFM, DSC, TGA and PXRD. The mechanical properties and in vitro drug release were determined using standard methods. TDF existed in crystalline form and the particles remained in the nano-range in redispersed films. TDF nanocrystals were embedded in the polymeric matrix and the drug loaded films were rough on the surface. Mechanical properties of the films varied with changes in drug load and surfactant. Significant changes in the disintegration times were noticed in films containing surfactants compared to surfactant-free films. About 80% of the drug release was observed between 3 and 30 min. TPGS showed better TDF release from the films at different drug loads

Place, publisher, year, edition, pages
Elsevier, 2017. Vol. 109, 372-380 p.
National Category
Other Health Sciences
Research subject
Health Science
Identifiers
URN: urn:nbn:se:ltu:diva-65226DOI: 10.1016/j.ejps.2017.08.019PubMedID: 28823854Scopus ID: 2-s2.0-85028524027OAI: oai:DiVA.org:ltu-65226DiVA: diva2:1134721
Note

Validerad;2017;Nivå 2;2017-09-12 (andbra)

Available from: 2017-08-21 Created: 2017-08-21 Last updated: 2017-09-12Bibliographically approved

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CiteExportLink to record
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