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Användbarheten av diffusionsviktade sekvenser vid MRT för att påvisa uteruscancer En litteraturstudie
Luleå University of Technology, Department of Health Sciences. (petana-5@student.ltu.se)
Luleå University of Technology, Department of Health Sciences.
2018 (Swedish)Independent thesis Basic level (professional degree), 180 HE creditsStudent thesis
Abstract [sv]

Inledning: Uteruscancer är den sjätte vanligaste cancerformen hos kvinnor i världen. Ny forskning pekar på att diffusionsviktad magnetresonanstomografi (MRT) kan vara en tillförlitlig undersökningsmetod för att detektera patologiska förändringar i uterus. Syfte: Att skapa en översikt av användbarheten av diffusionsviktade sekvenser vid MRT för att påvisa uteruscancer. Metod: Allmän litteraturöversikt, tio kvantitativa studier inkluderades. Resultat: Diffusionsviktade sekvenser vid MRT har högre sensitivitet, specificitet samt diagnostisk noggrannhet för att påvisa patologiska förändringar i uterus än sekvenser utan diffusionsviktning. Apparent diffusion coefficient (ADC) och b-värden är viktiga markörer för att skilja malign från benign vävnad, indikera patologisk parametrieinvasion samt förutse överlevnad hos patienter med cervixcancer. Slutsats: Diffusionsviktade sekvenser är bättre än sekvenser utan diffusionsviktning och kontrastmedelsförstärkta sekvenser på att hitta samt stadieindela tidiga förändringar i uterus. Undersökningen görs non-invasiv och säker för patienter med känslighet eller allergi mot kontrastmedel, samt frigör tid för röntgensjuksköterskan till omvårdnad av patienten.

Abstract [en]

Background: Uterus cancer is the sixth most common form of cancer in women in the world. New research suggests that diffusion-weighted magnetic resonance imaging (MRI) can be a reliable method of investigation for detecting pathological changes in the uterus. Purpose: To provide an overview of the available scientific support for the use of diffusion-weighted sequences in MRI to detect uterine cancer. Method: Literature review that included ten quantitative studies. Results: Diffusion-weighted sequences in MRI have higher sensitivity, specificity and diagnostic accuracy to detect pathological changes in the uterus compared to non- diffusion-weighted sequences. Apparent diffusion coefficient (ADC) and b-values are important markers to distinguish malignant from benign tissue, indicate pathological parametric invasion, and predict survival in patients with cervical cancer. Conclusion: Diffusion-weighted sequences are better than sequences without diffusion-weighting and contrast-mediated sequences for identifying and staging early changes in the uterus. The examination is made non-invasive and safe for patients with sensitivity or allergies toward contrast media, as well as freeing time for the radiographer to care for the patient.

Place, publisher, year, edition, pages
2018.
Keywords [en]
Uterus cancer, diffusion-weighted imaging, sensitivity, specificity, diagnostic accuracy, ADC, b-value.
Keywords [sv]
Uteruscancer, diffusionsviktad MRT, sensitivitet, specificitet, diagnostisk noggrannhet, ADC, b-värde.
National Category
Medical and Health Sciences Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:ltu:diva-67298OAI: oai:DiVA.org:ltu-67298DiVA, id: diva2:1174851
Subject / course
Student thesis, at least 15 credits
Educational program
Diagnostic Radiology Nursing, bachelor's level
Supervisors
Examiners
Available from: 2018-01-24 Created: 2018-01-16 Last updated: 2018-01-24Bibliographically approved

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