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Porous Hydroxyapatite-Bioactive Glass Hybrid Scaffolds Fabricated via Ceramic Honeycomb Extrusion
Luleå University of Technology, Department of Health Sciences, Medical Science. Department of Mechanical Engineering, University of Sheffield, Sheffield, United Kingdom; .ORCID iD: 0000-0003-1304-3686
Department of Materials Science and Engineering, University of Sheffield, Sheffield, UK.
Department of Materials Science and Engineering, University of Sheffield, Sheffield, UK.
2018 (English)In: Journal of The American Ceramic Society, ISSN 0002-7820, E-ISSN 1551-2916, Vol. 101, no 8, p. 3541-3556Article in journal (Refereed) Published
Abstract [en]

The successful fabrication of hydroxyapatite-bioactive glass scaffolds using honeycomb extrusion is presented herein. Hydroxyapatite was combined with either 10 wt% stoichiometric Bioglass® (BG1), calcium-excess Bioglass® (BG2) or canasite (CAN). For all composite materials, glass-induced partial phase transformation of the HA into the mechanically weaker β-tricalcium phosphate (TCP) occurred but XRD data demonstrated that BG2 exhibited a lower volume fraction of TCP than BG1. Consequently, the maximum compressive strength observed for BG1 and BG2 were 30.3 ± 3.9 and 56.7 ± 6.9 MPa, respectively, for specimens sintered at 1300 °C. CAN scaffolds, in contrast, collapsed when handled when sintered below 1300 °C, and thus failed. The microstructure illustrated a morphology similar to that of BG1 sintered at 1200 °C, and hence a comparable compressive strength (11.4 ± 3.1 MPa). The results highlight the great potential offered by honeycomb extrusion for fabricating high-strength porous scaffolds. The compressive strengths exceed that of commercial scaffolds, and biological tests revealed an increase in cell viability over seven days for all hybrid scaffolds. Thus it is expected that the incorporation of 10 wt% bioactive glass will provide the added advantage of enhanced bioactivity in concert with improved mechanical stability.

Place, publisher, year, edition, pages
John Wiley & Sons, 2018. Vol. 101, no 8, p. 3541-3556
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Other Health Sciences
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Health Science
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URN: urn:nbn:se:ltu:diva-67777DOI: 10.1111/jace.15514ISI: 000434278100033Scopus ID: 2-s2.0-85048344228OAI: oai:DiVA.org:ltu-67777DiVA, id: diva2:1185876
Note

Validerad;2018;Nivå 2;2018-06-07 (svasva)

Available from: 2018-02-26 Created: 2018-02-26 Last updated: 2018-08-16Bibliographically approved

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Elbadawi, Mohammed

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