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Biological Production of 3-Hydroxypropionic Acid: An Update on the Current Status
Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Chemical Engineering.ORCID iD: 0000-0002-3687-6173
Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Chemical Engineering.
Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Chemical Engineering.ORCID iD: 0000-0001-7500-2367
Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Chemical Engineering.ORCID iD: 0000-0003-0079-5950
2018 (English)In: Fermentation, ISSN 2311-5637, Vol. 4, no 1, article id 13Article in journal (Refereed) Published
Abstract [en]

The production of high added-value chemicals from renewable resources is a necessity inour attempts to switch to a more sustainable society. 3-Hydroxypropionic acid (3HP) is a promisingmolecule that can be used for the production of an important array of high added-value chemicals,such as 1,3-propanediol, acrylic acid, acrylamide, and bioplastics. Biological production of 3HP hasbeen studied extensively, mainly from glycerol and glucose, which are both renewable resources.To enable conversion of these carbon sources to 3HP, extensive work has been performed to identifyappropriate biochemical pathways and the enzymes that are involved in them. Novel enzymeshave also been identified and expressed in host microorganisms to improve the production yieldsof 3HP. Various process configurations have also been proposed, resulting in improved conversionyields. The intense research efforts have resulted in the production of as much as 83.8 g/L 3HP fromrenewable carbon resources, and a system whereby 3-hydroxypropionitrile was converted to 3HPthrough whole-cell catalysis which resulted in 184.7 g/L 3HP. Although there are still challengesand difficulties that need to be addressed, the research results from the past four years have been animportant step towards biological production of 3HP at the industrial level.

Place, publisher, year, edition, pages
MDPI , 2018. Vol. 4, no 1, article id 13
Keyword [en]
3-hydroxypropionic acid; metabolic engineering; building-block chemicals; glycerol; platform chemicals; Klebsiella pneumoniae; Escherichia coli; Saccharomyces cerevisiae
National Category
Industrial Biotechnology Bioprocess Technology
Research subject
Biochemical Process Engineering
Identifiers
URN: urn:nbn:se:ltu:diva-67793DOI: 10.3390/fermentation4010013OAI: oai:DiVA.org:ltu-67793DiVA, id: diva2:1186390
Available from: 2018-02-28 Created: 2018-02-28 Last updated: 2018-03-06Bibliographically approved

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Publisher's full texthttp://www.mdpi.com/2311-5637/4/1/13

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