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Chronic airway obstruction in a population-based adult asthma cohort: Prevalence, incidence and prognostic factors
Department of Public Health and Clinical Medicine, Division of Occupational and Environmental Medicine, The OLIN Unit, Umeå University.
Department of Public Health and Clinical Medicine, Division of Occupational and Environmental Medicine/the OLIN Unit, Umeå University.
Luleå University of Technology, Department of Health Sciences, Nursing Care.ORCID iD: 0000-0001-6622-3838
Real-World Evidence&Epidemiology, GSK R&D.
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2018 (English)In: Respiratory Medicine, ISSN 0954-6111, E-ISSN 1532-3064, Vol. 138, p. 115-122Article in journal (Refereed) Published
Abstract [en]

Background

Asthma and COPD may overlap (ACO) but information about incidence and risk factors are lacking. This study aimed to estimate prevalence, incidence and risk factors of chronic airway obstruction (CAO) in a population-based adult asthma cohort.

Methods

During 1986–2001 a large population-based asthma cohort was identified (n = 2055, 19-72y). Subsamples have participated in clinical follow-ups during the subsequent years. The entire cohort was invited to a clinical follow-up including interview, spirometry, and blood sampling in 2012–2014 when n = 983 subjects performed adequate spirometry. CAO was defined as post-bronchodilator FEV1/FVC<0.7.

Results

At study entry, asthmatics with prevalent CAO (11.4%) reported more respiratory symptoms, asthma medication use, and ischemic heart disease than asthmatics without CAO (asthma only). Subjects who developed CAO during follow-up (17.6%; incidence rate of 16/1000/year) had a more rapid FEV1 decline and higher levels of neutrophils than asthma only. Smoking, older age and male sex were independently associated with increased risk for both prevalent and incident CAO, while obesity had a protective effect.

Conclusions

In this prospective adult asthma cohort, the majority did not develop CAO. Smoking, older age and male sex were risk factors for prevalent and incident CAO, similar to risk factors described for COPD in the general population.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 138, p. 115-122
National Category
Nursing Other Health Sciences
Research subject
Nursing; Health Science
Identifiers
URN: urn:nbn:se:ltu:diva-68195DOI: 10.1016/j.rmed.2018.03.036Scopus ID: 2-s2.0-85045212522OAI: oai:DiVA.org:ltu-68195DiVA, id: diva2:1195448
Note

Validerad;2018;Nivå 2;2018-04-13 (rokbeg)

Available from: 2018-04-05 Created: 2018-04-05 Last updated: 2018-04-23Bibliographically approved

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