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Neurofilament light and tau as blood biomarkers for sports-related concussion
University of Gothenburg, Sahlgrenska Academy, Institute of Neuroscience & Physiology, Department of Psychiatry & Neurochemistry, Gothenburg, Sweden. Sahlgrens University Hospital, Neurochem Lab, Molndal, Sweden.
Luleå University of Technology, Department of Health Sciences, Medical Science.ORCID iD: 0000-0003-3628-0705
Department of Neurology, Skåne University Hospital, Lund University, Sweden.
University of Gothenburg, Sahlgrenska Academy, Institute of Neuroscience & Physiology, Department of Psychiatry & Neurochemistry, Gothenburg, Sweden. Sahlgrens University Hospital, Neurochem Lab, Molndal, Sweden.
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2018 (English)In: Neurology, ISSN 0028-3878, E-ISSN 1526-632X, Vol. 90, no 20, p. e1780-e1788Article in journal (Refereed) Published
Abstract [en]

Objective To compare neurofilament light (NfL) and tau as blood-based biomarkers for acute sports-related concussion (SRC) and determine whether their concentrations at different time points after the injury are associated with prolonged time to return to play (RTP).

Methods A total of 288 professional hockey players were followed longitudinally from September 1, 2012, to April 30, 2015. Data collection and biomarker analyses were conducted between 2015 and 2017. Associations were tested between blood concentrations of NfL and tau, and RTP time. Serum concentrations of S100B and neuron-specific enolase (NSE) were also measured for comparison.

Results Of 288 players, 105 sustained an SRC. Of these, 87 underwent blood sampling 1, 12, 36, and 144 hours after SRC and at the RTP time point. Serum NfL concentrations 1, 12, 36, and 144 hours after SRC were related to prolonged RTP time, and could separate players with RTP >10 days from those with RTP ≤10 days (area under the receiver operating characteristic curve [AUROC] 0.82). Also, serum NfL 144 hours after SRC discriminated players who resigned from the game due to persistent postconcussion symptoms (PCS) from those who returned to play (AUROC 0.89). Plasma tau 1 hour after SRC was related to RTP but less strongly than NfL, while S100B and NSE showed no such associations.

Conclusion Serum NfL outperformed tau, S100B, and NSE as a biomarker for SRC. From a clinical standpoint, serum NfL may be useful to identify individuals at risk of prolonged PCS, and may aid in biomarker-informed decisions with regard to when RTP should be considered.

Place, publisher, year, edition, pages
Wolters Kluwer, 2018. Vol. 90, no 20, p. e1780-e1788
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Other Health Sciences
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Health Science
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URN: urn:nbn:se:ltu:diva-68381DOI: 10.1212/WNL.0000000000005518ISI: 000439159900006PubMedID: 29653990OAI: oai:DiVA.org:ltu-68381DiVA, id: diva2:1198330
Note

Validerad;2018;Nivå 2;2018-08-08 (rokbeg)

Available from: 2018-04-17 Created: 2018-04-17 Last updated: 2019-03-27Bibliographically approved

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