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Inkjet Printing of T3 and T4 Oral Drug Combinations as a Novel Strategy for Hypothyroidism
UCL School of Pharmacy, University College London.
Luleå University of Technology, Department of Health Sciences, Medical Science. UCL School of Pharmacy, University College London.ORCID iD: 0000-0003-2645-5719
UCL School of Pharmacy, University College London.
UCL School of Pharmacy, University College London.
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2018 (English)In: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476Article in journal (Refereed) Epub ahead of print
Abstract [en]

Hypothyroidism is a chronic and debilitating disease that is estimated to affect 3% of the general population. Clinical experience has highlighted the synergistic value of combining triiodothyronine (T3) and thyroxine (T4) for persistent or recurrent symptoms. However, thus far a platform that enables the simultaneous and independent dosing of more than one drug for oral administration has not been developed. Thermal inkjet (TIJ) printing is a potential solution to enable the dual deposition of T3 and T4 onto orodispersible films (ODFs) for therapy personalisation. In this study, a two-cartridge TIJ printer was modified such that it could print separate solutions of T3 and T4. Dose adjustments were achieved by printing solutions adjacent to each other, enabling therapeutic T3 (15–50 μg) and T4 dosages (60–180 μg) to be successfully printed. Excellent linearity was observed between the theoretical and measured dose for both T3 and T4 (R2 = 0.982 and 0.985, respectively) by changing the length of the print objective (Y-value). Rapid disintegration of the ODFs was achieved (< 45 seconds). As such, this study for the first time demonstrates the ability to produce personalised dose combinations by TIJ printing T3 and T4 onto the same substrate for oral administration.

Place, publisher, year, edition, pages
Elsevier, 2018.
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Other Health Sciences
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Health Science
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URN: urn:nbn:se:ltu:diva-70202DOI: 10.1016/j.ijpharm.2018.07.062PubMedID: 30063938OAI: oai:DiVA.org:ltu-70202DiVA, id: diva2:1236772
Available from: 2018-08-06 Created: 2018-08-06 Last updated: 2018-08-06

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Vuddanda, Parameswara RaoVelaga, Sitaram

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