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Biocatalytic synthesis of fungal β-glucans
Biotechnology Laboratory, School of Chemical Engineering, National Technical University of Athens.
Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Chemical Engineering.ORCID iD: 0000-0003-0361-7690
Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Chemical Engineering. Biotechnology Laboratory, School of Chemical Engineering, National Technical University of Athens.ORCID iD: 0000-0003-0078-5904
2018 (English)In: Catalysts, ISSN 2073-4344, Vol. 8, no 7, article id 274Article in journal (Refereed) Published
Abstract [en]

Glucans are the dominant polysaccharide constituents of fungal cell walls. Remarkably, these major bioactive polysaccharides account for the beneficial effects that have been observed by many mushrooms of medicinal interest. Accordingly, the prevailing tendency is the use of bioactive mushroom β-glucans mainly in pharmaceutical industries or as food additives, since it seems that they can be involved in meeting the overall growing demand for food in the future, but also in medical and material sectors. β-(1,3)-Glucan synthase (GLS) is the responsible enzyme for the synthesis of these important polysaccharides, which is a member of the glycosyl transferase (GT) family. For optimizing the production of such natural polymers of great interest, the comprehension of the fungal synthetic mechanism, as well as the biochemical and molecular characteristics of the key enzyme GLS and its expression seem to be crucial. Overall, in this review article, the fungal β-glucans biosynthesis by GLS is summarized, while the in vitro synthesis of major polysaccharides is also discussed, catalyzed by glycoside hydrolases (GHs) and GTs. Possible future prospects of GLS in medicine and in developing other potential artificial composite materials with industrial applications are also summarized

Place, publisher, year, edition, pages
MDPI AG , 2018. Vol. 8, no 7, article id 274
National Category
Bioprocess Technology
Research subject
Biochemical Process Engineering
Identifiers
URN: urn:nbn:se:ltu:diva-70268DOI: 10.3390/catal8070274ISI: 000440016400021Scopus ID: 2-s2.0-85050008185OAI: oai:DiVA.org:ltu-70268DiVA, id: diva2:1237254
Note

Validerad;2018;Nivå 2;2018-08-08 (andbra)

Available from: 2018-08-08 Created: 2018-08-08 Last updated: 2018-08-09Bibliographically approved

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Zerva, AnastasiaTopakas, Evangelos

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