In this article, the potential of utilizing a commercially available Electric Ducted Fan (EDF) as a negative-pressure actuator for adhesion purposes is experimentally tested. To this purpose, a novel EDF-based Vortex Actuation System (VAS) is proposed and presented from a design, development and experimental evaluation perspective. The effect of different EDF design properties and design alterations to the actuation system is analyzed, for providing novel considerations on optimizing the adhesion efficiency of such a system.