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Fabrication and characterization of novel bilayer scaffold from nanocellulose based aerogel for skin tissue engineering applications
Department of Wood and Paper Sciences and Technology, Faculty of Natural Resources, University of Tehran, Karaj, Iran.
Department of Wood and Paper Sciences and Technology, Faculty of Natural Resources, University of Tehran, Karaj, Iran.
Marquette University, School of Dentistry, Milwaukee, WI, USA.
Luleå University of Technology, Department of Engineering Sciences and Mathematics, Material Science.ORCID iD: 0000-0003-4762-2854
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2019 (English)In: International Journal of Biological Macromolecules, ISSN 0141-8130, E-ISSN 1879-0003, Vol. 136, p. 796-803Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to fabricate a novel bilayer scaffold containing cellulose nanofiber/poly (vinyl) alcohol (CNF/PVA) to evaluate its potential use in skin tissue engineering. Here, the scaffolds were fabricated using a novel one-step freeze-drying technique with two different concentrations of the aforementioned polymers. FE-SEM analysis indicated that the fabricated scaffolds had interconnected pores with two defined pore size in each layer of the bilayer scaffolds that can recapitulate the two layers of the dermis and epidermis of the skin. Lower concentration of polymers causes higher porosity with larger pore size and increased water uptake and decreased mechanical strength. FTIR proved the presence of functional groups and strong hydrogen bonding between the molecules of CNF/PVA and the efficient crosslinking. The MTT assay showed that these nanofibrous scaffolds meet the requirement as a biocompatible material for skin repair. Here, for the first time, we fabricated bilayer scaffold using a novel one-step freeze-drying technique only by controlling the polymer concentration with spending less time and energy.

Place, publisher, year, edition, pages
Elsevier, 2019. Vol. 136, p. 796-803
Keywords [en]
Bilayered scaffold, Cellulose nanofiber (CNF), Freeze-drying, Skin tissue engineering
National Category
Bio Materials
Research subject
Wood and Bionanocomposites
Identifiers
URN: urn:nbn:se:ltu:diva-75120DOI: 10.1016/j.ijbiomac.2019.06.104ISI: 000482533000080PubMedID: 31226370Scopus ID: 2-s2.0-85067698284OAI: oai:DiVA.org:ltu-75120DiVA, id: diva2:1332730
Note

Validerad;2019;Nivå 2;2019-06-28 (svasva)

Available from: 2019-06-28 Created: 2019-06-28 Last updated: 2019-09-13Bibliographically approved

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Oksman, Kristiina

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