Substitution of fossil gaseous fuels with biomass-based gases is of interest to the iron and steel industry due to its role in the mitigation of anthropogenic CO2emissions. In switching from fossil fuels to biomass-based gases, a systems analysis of the full value chain from biomass supply to the production and supply of final gas products becomes crucial. This study uses process and heat integration methods in combination with a supply chain evaluation to analyse full value chains of biomass-based gases for fossil gas replacement within the iron and steel industry. The study is carried out as a specific case study in order to understand the implications of utilizing bio-syngas/bio-SNG as heating fuels in iron- and steel-making, and to provide insights into the most sensitive parameters involved in fuel switching. The results show a significant cost difference in the fuel production of the two gas products owing to higher capital and biomass use in the bio-SNG value chain option. When tested for sensitivity, biomass price, transportation distance, and capital costs show the most impact on fuel production costs across all options studied. Trade-offs associated with process integration, plant localisation, feedstock availability and supply were found to varying extents.