A production block of the underground mine exploiting the Chelopech high sulphidation epithermal copper-gold deposit was subjected to geometallurgical modelling. This study details the procedure used based on traditional comminution and mineralogical indices. Drop weight and batch grinding tests were performed on representative samples to yield parameters related to Axb and operating work OWi indices. These were further correlated with the ore mineralogical features using principal component analysis. Modal mineralogy data processed by a set of linear equations enabled the estimation of the aforementioned indices with a deviation of ±2.4 for Axb and ±9.08 kWh/t for OWi respectively. Based on ore textural characteristics and non-sulphide gangue (NSG) minerals content, two geometallurgical domains were identified as a first approach to modelling of the studied block.