Interfacial transfer at mesoscale is a common issue for all the multi-phase chemical processes, and the related study remains as a scientific challenge due to the complexities. Investigating the interfacial interactions at mesoscale to find out the regulation strategies is the key to realize process-intensification of mass-transfer and reaction for the advanced chemical industries. To accurately describe the behavior of fluids at the interface, a new molecular thermodynamic model that can describe the complex fluid-solid interface interaction. When the molecular thermodynamic modeling method is extended to the nano-micro interfacial transfer needs to be developed, calling for the coordination of advanced experiments at nano-micro scale and molecular with molocular thermodynamic modelling. Atomic force microscopy (AFM), which possess the sensitivity down to nanoscale, can directly obtain the interfacial interaction at nano-micro scale. The quantification of AFM-measured forces can be used to construct the coarse-grained molecular model and describe complex interfacial interaction. Then, the coarse-grained molecular model can reveal the molecular thermodynamic mechanism of nano- and micro- interface transfer, realizing quantitative prediction.