To better understand the mechanical behavior in a jointed rock mass, a series of uniaxial compression tests were conducted on non-persistently jointed rock specimens with double circular holes. Acoustic emission (AE) and digital image correlation (DIC) techniques were applied to capture micro-crack events and real-time strain field evolution in the specimens. The results indicate that the existence of non-persistent joints has a significant influence on the strength characteristics of the specimens. Specifically, peak strength decreases at first and reaches a minimum at 30° then increases with increase in the joint dip angle. DIC technology has successfully monitored the development of surface strain fields. The fracture evolution process is comprehensively understood. Every sudden change in a strain field is usually accompanied by apparent AE events and stress–strain curves take the form of oscillations. The crack coalescence modes among joints can be summarized as six types and the crack coalescence patterns around holes and joints can be divided into three categories. These results are helpful to understanding further the mechanical properties and fracture mechanism of openings in non-persistently jointed rock masses.