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Metabolic Engineering of Lysine Producing Corynebacterium glutamicum Strains
Institute for Food Biotechnology and Genomics, National Academy of Sciences of Ukraine, Kyiv, Ukraine.
Luleå University of Technology, Department of Engineering Sciences and Mathematics, Wood Science and Engineering.ORCID iD: 0000-0002-4965-5193
Institute for Food Biotechnology and Genomics, National Academy of Sciences of Ukraine, Kyiv, Ukraine.
Institute for Food Biotechnology and Genomics, National Academy of Sciences of Ukraine, Kyiv, Ukraine.
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2020 (English)In: Cytology and Genetics, ISSN 0095-4527, Vol. 54, no 2, p. 137-146Article, review/survey (Refereed) Published
Abstract [en]

The review is devoted to the analysis of the current achievements of Corynebacterium glutamicum metabolic engineering for the production of lysine. Key genes of lysine biosynthesis in C. glutamicum and ways of creating new genetically modified strains are considered. The role of different plasmids, vector cassettes, and promoter types for the regulation of gene expression in C. glutamicum is described. Information is provided on the use of carbon-containing substrates (hexose, pentose, lactic acid, mannitol) for the production of lysine. Possibilities of using CRISPR technology in genetic engineering of C. glutamicum are considered. Genetic changes in C. glutamicum allowed the use of alternative substrates and contributed to the increase of lysine accumulation in the culture fluid. The data that may be used for the creation of new lysine overproduction strains are summarized.

Place, publisher, year, edition, pages
Springer, 2020. Vol. 54, no 2, p. 137-146
Keywords [en]
Corynebacterium glutamicum, producer strain, microbiological synthesis, lysine, metabolic engineering
National Category
Other Mechanical Engineering
Research subject
Wood Science and Engineering
Identifiers
URN: urn:nbn:se:ltu:diva-78724DOI: 10.3103/S0095452720020024ISI: 000524261800008Scopus ID: 2-s2.0-85083222047OAI: oai:DiVA.org:ltu-78724DiVA, id: diva2:1427484
Note

Validerad;2020;Nivå 2;2020-05-05 (johcin)

Available from: 2020-04-29 Created: 2020-04-29 Last updated: 2024-03-27Bibliographically approved

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Sekan, Alona

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