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Development of a Highly Proliferated Bilayer Coating on 316L Stainless Steel Implants
Department of Chemical Engineering, Isfahan University of Technology, Isfahan 8415683111, Iran.
Department of Chemical Engineering, Isfahan University of Technology, Isfahan 8415683111, Iran.
Department of Chemical Engineering, Isfahan University of Technology, Isfahan 8415683111, Iran.
Department of Materials and Polymer Engineering, Faculty of Engineering, Hakim Sabzevari University, Sabzevar 9617976487, Iran.
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2020 (English)In: Polymers, E-ISSN 2073-4360, Vol. 12, no 5, article id 1022Article in journal (Refereed) Published
Abstract [en]

In this research, a bilayer coating has been applied on the surface of 316 L stainless steel (316LSS) to provide highly proliferated metallic implants for bone regeneration. The first layer was prepared using electrophoretic deposition of graphene oxide (GO), while the top layer was coated utilizing electrospinning of poly (ε-caprolactone) (PCL)/gelatin (Ge)/forsterite solutions. The morphology, porosity, wettability, biodegradability, bioactivity, cell attachment and cell viability of the prepared coatings were evaluated. The Field Emission Scanning Electron Microscopy (FESEM) results revealed the formation of uniform, continuous, and bead-free nanofibers. The Energy Dispersive X-ray (EDS) results confirmed well-distributed forsterite nanoparticles in the structure of the top coating. The porosity of the electrospun nanofibers was found to be above 70%. The water contact angle measurements indicated an improvement in the wettability of the coating by increasing the amount of nanoparticles. Furthermore, the electrospun nanofibers containing 1 and 3 wt.% of forsterite nanoparticles showed significant bioactivity after soaking in the simulated body fluid (SBF) solution for 21 days. In addition, to investigate the in vitro analysis, the MG-63 cells were cultured on the PCL/Ge/forsterite and GO-PCL/Ge/forsterite coatings. The results confirmed an excellent cell adhesion along with considerable cell growth and proliferation. It should be also noted that the existence of the forsterite nanoparticles and the GO layer substantially enhanced the cell proliferation of the coatings.

Place, publisher, year, edition, pages
MDPI, 2020. Vol. 12, no 5, article id 1022
Keywords [en]
biocomposites, nanofibers, electrospinning, cell culture, graphene oxide
National Category
Bio Materials
Research subject
Wood and Bionanocomposites
Identifiers
URN: urn:nbn:se:ltu:diva-78865DOI: 10.3390/polym12051022ISI: 000541431100027PubMedID: 32369977Scopus ID: 2-s2.0-85085389763OAI: oai:DiVA.org:ltu-78865DiVA, id: diva2:1429731
Note

Validerad;2020;Nivå 2;2020-05-12 (alebob)

Available from: 2020-05-12 Created: 2020-05-12 Last updated: 2024-01-17Bibliographically approved

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