Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Buccal Delivery of Nanoparticles
Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile. Advanced Center for Chronic Diseases (ACCDiS), Santiago, Chile.
Luleå University of Technology, Department of Health Sciences, Medical Science. Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile. Advanced Center for Chronic Diseases (ACCDiS), Santiago, Chile.ORCID iD: 0000-0002-3190-2168
2020 (English)In: Mucosal Delivery of Drugs and Biologics in Nanoparticles / [ed] Pavan Muttil, Nitesh K. Kunda, Springer, 2020, p. 107-124Chapter in book (Other academic)
Abstract [en]

The buccal route offers an alternative for drug administration due to its advantages, including the avoidance of the gastrointestinal tract, the hepatic first-pass, enzymatic degradation and chemical instability of certain molecules that would pose a challenge to formulate orally. Moreover, the oral cavity has a lower enzyme content than the rest of the gastrointestinal tract, predictable transit times, easy administration, and provides the opportunity to readily halt drug administration. Additionally, the oral cavity is an organized system with stratified epithelium that allows manufacturing of pharmaceutical forms for drug delivery.

Due to the possibilities offered by this route, recent research efforts have been conducted towards the use of nanotechnology to enable buccal drug delivery. In this chapter, we discuss the anatomy of the oral cavity, relevant characteristics of the epithelium to drug delivery and delivery system permeation, types of nanocarriers that have been reported to-date and toxicity studies addressing nanotechnology.

Place, publisher, year, edition, pages
Springer, 2020. p. 107-124
Series
AAPS Advances in the Pharmaceutical Sciences Series, ISSN 2210-7371, E-ISSN 2210-738X ; 41
Keywords [en]
Buccal absorption, Nanocarriers, Nanoparticle safey, Ex vivo permeation, Mucoadhesion, Buccal drug delivery
National Category
Other Health Sciences
Research subject
Health Science
Identifiers
URN: urn:nbn:se:ltu:diva-80719DOI: 10.1007/978-3-030-35910-2_5Scopus ID: 2-s2.0-85090055148OAI: oai:DiVA.org:ltu-80719DiVA, id: diva2:1464662
Note

ISBN för värdpublikation: 978-3-030-35909-6, 978-3-030-35910-2

Available from: 2020-09-07 Created: 2020-09-07 Last updated: 2020-09-07Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textScopus

Authority records

Morales, Javier O.

Search in DiVA

By author/editor
Morales, Javier O.
By organisation
Medical Science
Other Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 47 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf