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Utilizing the Natural Composition of Brown Seaweed for the Preparation of Hybrid Ink for 3D Printing of Hydrogels
Luleå University of Technology, Department of Engineering Sciences and Mathematics, Material Science.ORCID iD: 0000-0002-6247-5963
The Center for Disaster Medicine and Traumatology, and Experimental Plastic Surgery, Department of Biomedical and Clinical Sciences, Linköping University, SE-581 83 Linköping, Sweden.
The Center for Disaster Medicine and Traumatology, and Experimental Plastic Surgery, Department of Biomedical and Clinical Sciences, Linköping University, SE-581 83 Linköping, Sweden.
Luleå University of Technology, Department of Engineering Sciences and Mathematics, Fluid and Experimental Mechanics.ORCID iD: 0000-0001-7395-3302
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2020 (English)In: ACS Applied Bio Materials, E-ISSN 2576-6422, Vol. 3, no 9, p. 6510-6520Article in journal (Refereed) Published
Abstract [en]

This study aims to utilize the natural composition of brown seaweed by deriving alginate and cellulose concurrently from the stipe (stem-like) and blade (leaf-like) structures of the seaweed; further, this is followed by fibrillation for the direct and resource-efficient preparation of alginate/cellulose nanofiber (CNF) hybrid inks for three-dimensional (3D) printing of hydrogels. The efficiency of the fibrillation process was evaluated, and the obtained gels were further studied with regard to their rheological behavior. As a proof of concept, the inks were 3D printed into discs, followed by cross-linking with CaCl2 to form biomimetic hydrogels. It was shown that the nanofibrillation process from both seaweed structures is very energy-efficient, with an energy demand lower than 1.5 kW h/kg, and with CNF dimensions below 15 nm. The inks displayed excellent shear-thinning behavior and cytocompatibility and were successfully printed into 3D discs that, after cross-linking, exhibited an interconnected network structure with favorable mechanical properties, and a cell viability of 71%. The designed 3D biomimetic hydrogels offers an environmentally benign, cost-efficient, and biocompatible material platform with a favorable structure for the development of biomedical devices, such as 3D bio printing of soft tissues.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2020. Vol. 3, no 9, p. 6510-6520
Keywords [en]
alginate, cellulose nanofibers, 3D printing, biomimetic hydrogels, biomedical application, tissue engineering
National Category
Bio Materials Applied Mechanics
Research subject
Wood and Bionanocomposites; Experimental Mechanics
Identifiers
URN: urn:nbn:se:ltu:diva-81289DOI: 10.1021/acsabm.0c00920ISI: 000604600600100PubMedID: 35021782Scopus ID: 2-s2.0-85093660963OAI: oai:DiVA.org:ltu-81289DiVA, id: diva2:1485398
Note

Validerad;2020;Nivå 1;2020-12-03 (alebob)

Available from: 2020-11-02 Created: 2020-11-02 Last updated: 2023-10-14Bibliographically approved

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Berglund, LinnForsberg, FredrikOksman, Kristiina

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