Water scarcity has been intensified globally due to the rapid growth of economic and population. Wastewater treatment and recycling is one of the most feasible strategies for meeting the ever-increasing water usage. However, conventional centralized wastewater treatment plants are being stretched to their limits with the emerging urban structures. To mitigate this situation, this paper proposes a decentralized treatment solution for domestic wastewater leveraging the recent advancements in instrumentation, automation, and information technologies. In particular, a 60-ton adjustable secondary wastewater treatment facility has been designed as a foundation, upon which in-situ monitoring, software-centric automation system, and industrial edge-cloud computing platform have been deployed to form a holistic solution. The resultant facility has been consecutively and successfully operating onsite to date.