Layered rock masses with joints are widely found in nature. Their mechanical behavior plays a key role in rock engineering applications. However, previous studies have concentrated on the single lithologic layer, and few studies have reported the crack coalescence mechanism in layered rock masses with joints. In this study, uniaxial compression tests were performed on jointed rock-like specimens with two dissimilar layers. The acoustic emission (AE) and the digital image correlation (DIC) techniques are employed to investigate the crack coalescence process of specimens with two dissimilar layers. The influence of the joint angle and rock bridge angle on the mechanical behavior and failure processes in layered rock masses is investigated. The results show that the peak strength is associated with the joint angle and the rock bridge angle. Seven types of crack coalescence have been identified in the specimens, which are not only related to the joint angle and the rock bridge angle but also influenced by the rock layers. Cracks easily coalesce when the joint angle and the rock bridge angle are small. However, when the joint angle and the rock bridge angle are larger, it is difficult for cracks to initiate and propagate in the layer with higher strength. The failure mechanism of the specimens is primarily caused by crack propagation in the layer with lower strength.