Operator 4.0 is a smart and skilled operator who augments the symbiosis between intelligent machines and operators. Better integration of Operator 4.0 in Industry 4.0 can bring emphasis on the human-centric approach, allowing for a paradigm shift towards human-automation cooperation for inspiring the compulsion of human-in-the-loop. This further enhances the domain knowledge for the improvement of human cyber-physical systems for new generation automated systems. This cooperation of humans and automation makes stability in socio-technical systems with smart automation and human-machine interfacing technologies. This chapter discusses the design principles of Industry 4.0 and Operator 4.0 human-cyber physical systems.