Control systems need to be able to operate under uncertainty and especially under attacks. To address such challenges, this paper formulates the solution of robust control for uncertain systems under time-varying and unknown time-delay attacks in cyber-physical systems (CPSs). A novel control method able to deal with thwart time-delay attacks on closed-loop control systems is proposed. Using a descriptor model and an appropriate Lyapunov functional, sufficient conditions for closed-loop stability are derived based on linear matrix inequalities (LMIs). A design procedure is proposed to obtain an optimal state feedback control gain such that the uncertain system can be resistant under an injection time-delay attack with variable delay. Furthermore, various fault detection frameworks are proposed by following the dynamics of the measured data at the system's input and output using statistical analysis such as correlation analysis and K-L (Kullback-Leibler) divergence criteria to detect attack's existence and to prevent possible instability. Finally, an example is provided to evaluate the proposed design method's effectiveness.