One of the challenges in the processing of sulphide ores is the recovery of gangue minerals, such as talc. Talc can be even more problematic as it degrades the concentrate and can impose problems in the downstream metallurgical processes, such as smelting. Unfortunately, talc’s natural hydrophobicity makes it easier to recover, and most used depressants have poor selectivity towards it. This study evaluated the changes in flotation kinetics when using hydrodynamic cavitation (HC) in the reagentless and collectorless talc (and chalcopyrite) flotation with respect to the conventional flotation without HC. Furthermore, the effect of hydrodynamic variables, specifically impeller tip speed and superficial gas velocity, on the flotation kinetics of talc was evaluated to determine the best parameter values to be used for this study. The effect of frother and HC introduction was also studied in both talc and chalcopyrite minerals in different single mineral flotation experiments. Results showed that the best talc flotation performance was observed in the setting: 2.8 m/s impeller tip speed and 0.14 cm/s superficial gas velocity. Methyl Isobutyl Carbinol (MIBC) was shown to increase the flotation kinetics and overall talc recovery better than pine oil but not in chalcopyrite; thus, it can be considered an ideal frother to separate talc in a talc-chalcopyrite mixture. HC improved the flotation kinetics and recovery in a reagentless flotation but not in the collectorless flotation where frothers are added. Based on the results, the conventional collectorless flotation with MIBC is the condition that will give the best talc-chalcopyrite separation. Furthermore, 7 minutes is considered the optimum or recommended time for the froth collection as the difference in the recovery of the two minerals hardly improved or increased afterwards. However, the predicted separation of talc from other minerals using the recommended condition was not observed in the artificial ore flotation tests conducted. Overall, this study aims to investigate the flotation behavior or flotation response of ultrafine talc particles when their natural hydrophobicity is exploited through collectorless and reagentless flotation. The effect of the hydrodynamic variables specifically impeller tip speed and superficial gas velocity, and the introduction of frother and HC in the system is the primary focus of this study.