In this study, the AdaBoost, MultiBoost and RealAdaBoost methods were combined with the Quadratic Discriminant Analysis method to develop three new GIS-based Machine Learning ensemble models, i.e., ABQDA, MBQDA, and RABQDA for groundwater potential mapping in the Dak Nong Province, Vietnam. In total, 227 groundwater wells and 12 conditioning factors (infiltration, rainfall, river density, topographic wetness index, sediment transport index, stream power index, elevation, aspect, curvature, slope, soil, and land use) were used for this study. Performance of the models was evaluated using the Area Under the Receiver Operating Characteristics Curve AUC (AUC) and several other performance metrics. The results showed that the ABQDA model that achieved AUC = 0.741 was superior to the other models in producing an accurate map of groundwater potential for the Dak Nong Province. The models and potential maps produced here can help policymakers and water resources managers to preserve an optimal exploit from these vital resources.