The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER)Faculté de Médecine, INSERM-University of Toulouse UMR1295 (CERPOP), Toulouse, France; Department of Epidemiology and Public Health, Toulouse University Hospital, Toulouse, France.
Center for Life Course Health Research, University of Oulu, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.
Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Neurocenter, Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
Department of Public Health and Welfare, Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
Department of Public Health and Welfare, Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Joint municipal authority for North Karelia social and health services (Siun sote), Joensuu, Finland.
Finnish Institute of Occupational Health, Helsinki, Finland.
Department of Public Health and Welfare, Functioning and Service Needs Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
Department of Public Health and Welfare, Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Stockholm, Sweden.
Center for Life Course Health Research, University of Oulu, Oulu, Finland; Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Department of Public Health and Welfare, Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland; Department of Public Health, University of Helsinki, Helsinki, Finland; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia; South Ostrobothnia Central Hospital, Seinäjoki, Finland.
Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland; Neurocenter, Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
Department of Public Health and Welfare, Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Stockholm, Sweden; Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, UK; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Theme Aging, Karolinska University Hospital, Solna, Sweden.
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2022 (English)In: Alzheimer's & Dementia: Journal of the Alzheimer's Association, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 18, no 7, p. 1325-1334Article in journal (Refereed) Published
Abstract [en]
Introduction: Lifestyle interventions may prevent cognitive decline, but the sufficient dose of intervention activities and lifestyle changes is unknown. We investigated how intervention adherence affects cognition in the FINGER trial (pre-specified subgroup analyses).
Methods: FINGER is a multicenter randomized controlled trial examining the efficacy of multidomain lifestyle intervention (ClinicalTrials.gov NCT01041989). A total of 1260 participants aged 60 to 77 with increased dementia risk were randomized to a lifestyle intervention and control groups. Percentage of completed intervention sessions, and change in multidomain lifestyle score (self-reported diet; physical, cognitive, and social activity; vascular risk) were examined in relation to change in Neuropsychological Test Battery (NTB) scores.
Results: Active participation was associated with better trajectories in NTB total and all cognitive subdomains. Improvement in lifestyle was associated with improvement in NTB total and executive function.
Discussion: Multidomain lifestyle changes are beneficial for cognitive functioning, but future interventions should be intensive enough, and supporting adherence is essential.
Place, publisher, year, edition, pages
John Wiley & Sons, 2022. Vol. 18, no 7, p. 1325-1334
Keywords [en]
cognition, lifestyle, multidomain, prevention
National Category
Neurology
Research subject
Engineering Psychology
Identifiers
URN: urn:nbn:se:ltu:diva-87619DOI: 10.1002/alz.12492ISI: 000715153800001PubMedID: 34668644Scopus ID: 2-s2.0-85117342353OAI: oai:DiVA.org:ltu-87619DiVA, id: diva2:1605542
Note
Validerad;2022;Nivå 2;2022-08-02 (hanlid);
For funding information, see: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12492
2021-10-252021-10-252023-03-28Bibliographically approved