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A label-free graphene-based impedimetric biosensor for real-time tracing of the cytokine storm in blood serum; suitable for screening COVID-19 patients
Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, University of Tehran, P. O. Box 14395/515, Tehran, Iran;Nano Electronic Center of Excellence, Thin Film and Nano Electronics Lab, School of Electrical and Computer Engineering, University of Tehran, P. O. Box 14395/515, Tehran, Iran;School of Mechanical Engineering, College of Engineering, University of Tehran, Tehran 11155-4563, Iran.ORCID iD: 0000-0002-6825-0247
Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, University of Tehran, P. O. Box 14395/515, Tehran, Iran;Nano Electronic Center of Excellence, Thin Film and Nano Electronics Lab, School of Electrical and Computer Engineering, University of Tehran, P. O. Box 14395/515, Tehran, Iran.
Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, University of Tehran, P. O. Box 14395/515, Tehran, Iran;Nano Electronic Center of Excellence, Thin Film and Nano Electronics Lab, School of Electrical and Computer Engineering, University of Tehran, P. O. Box 14395/515, Tehran, Iran.
Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, University of Tehran, P. O. Box 14395/515, Tehran, Iran;Nano Electronic Center of Excellence, Thin Film and Nano Electronics Lab, School of Electrical and Computer Engineering, University of Tehran, P. O. Box 14395/515, Tehran, Iran.ORCID iD: 0000-0001-8165-2737
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2021 (English)In: RSC Advances, E-ISSN 2046-2069, Vol. 11, no 55, p. 34503-34515Article in journal (Refereed) Published
Abstract [en]

Concurrent with the pandemic announcement of SARS-CoV-2 infection by the WHO, a variety of reports were published confirming the cytokine storm as the most mortal effect of the virus on the infected patients. Hence, cytokine storm as an evidenced consequence in most of the COVID-19 patients could offer a promising opportunity to use blood as a disease progression marker. Here, we have developed a rapid electrochemical impedance spectroscopy (EIS) sensor for quantifying the overall immune activity of the patients. Since during the cytokine storm many types of cytokines are elevated in the blood, there is no need for specific detection of a single type of cytokine and the collective behavior is just measured without any electrode functionalization. The sensor includes a monolayer graphene on a copper substrate as the working electrode (WE) which is able to distinguish between the early and severe stage of the infected patients. The charge transfer resistance (RCT) in the moderate and severe cases varies about 65% and 138% compared to the normal groups, respectively and a specificity of 77% and sensitivity of 100% based on ELISA results were achieved. The outcomes demonstrate a significant correlation between the total mass of the three main hypercytokinemia associated cytokines including IL-6, TNF-α and IFN-γ in patients and the RCT values. As an extra application, the biosensor's capability for diagnosis of COVID-19 patients was tested and a sensitivity of 92% and specificity of 50% were obtained compared to the RT-PCR results.

Place, publisher, year, edition, pages
Royal Society of Chemistry, 2021. Vol. 11, no 55, p. 34503-34515
Keywords [en]
General Chemical Engineering, General Chemistry
National Category
Nano Technology Infectious Medicine
Research subject
Machine Elements
Identifiers
URN: urn:nbn:se:ltu:diva-87708DOI: 10.1039/d1ra04298jISI: 000710480500001PubMedID: 35494759Scopus ID: 2-s2.0-85120046571OAI: oai:DiVA.org:ltu-87708DiVA, id: diva2:1607474
Note

Validerad;2021;Nivå 2;2021-11-04 (johcin)

Available from: 2021-11-01 Created: 2021-11-01 Last updated: 2022-09-15Bibliographically approved

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Fadaei Naeini, Vahid

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