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Ferulic Acid From Plant Biomass: A Phytochemical With Promising Antiviral Properties
Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Chemical Engineering.ORCID iD: 0000-0002-7754-9398
Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Chemical Engineering.ORCID iD: 0000-0002-5087-641x
Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Chemical Engineering.ORCID iD: 0000-0001-7500-2367
Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Chemical Engineering.ORCID iD: 0000-0003-0079-5950
2022 (English)In: Frontiers in Nutrition, E-ISSN 2296-861X, Vol. 8, article id 777576Article, review/survey (Refereed) Published
Abstract [en]

Plant biomass is a magnificent renewable resource for phytochemicals that carry bioactive properties. Ferulic acid (FA) is a hydroxycinnamic acid that is found widespread in plant cell walls, mainly esterified to polysaccharides. It is well known of its strong antioxidant activity, together with numerous properties, such as antimicrobial, anti-inflammatory and neuroprotective effects. This review article provides insights into the potential for valorization of FA as a potent antiviral agent. Its pharmacokinetic properties (absorption, metabolism, distribution and excretion) and the proposed mechanisms that are purported to provide antiviral activity are presented. Novel strategies on extraction and derivatization routes, for enhancing even further the antiviral activity of FA and potentially favor its metabolism, distribution and residence time in the human body, are discussed. These routes may lead to novel high-added value biorefinery pathways to utilize plant biomass toward the production of nutraceuticals as functional foods with attractive bioactive properties, such as enhancing immunity toward viral infections.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2022. Vol. 8, article id 777576
Keywords [en]
antiviral activity, nutraceuticals, plant biomass, extraction, ferulic acid, metabolism, enzymatic derivatization, immunity
National Category
Bioprocess Technology
Research subject
Biochemical Process Engineering
Identifiers
URN: urn:nbn:se:ltu:diva-89129DOI: 10.3389/fnut.2021.777576ISI: 000760450600001PubMedID: 35198583Scopus ID: 2-s2.0-85125083205OAI: oai:DiVA.org:ltu-89129DiVA, id: diva2:1635801
Note

Validerad;2022;Nivå 2;2022-03-02 (hanlid)

Available from: 2022-02-07 Created: 2022-02-07 Last updated: 2023-10-11Bibliographically approved

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Antonopoulou, IoSapountzaki, EleftheriaRova, UlrikaChristakopoulos, Paul

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