BackgroundOver the last three decades, consumption of total and saturated fat has steadily declined in Western diets as a proportion of calories intake. At the same time, omega (ω)-6 fatty acid intake has risen at the expense of ω-3 fatty acids, resulting in an ω-6/ω-3 ratio of 20:1 or higher.

Scope and approachThe observed changes in fatty acids ratio coincide with a significantly increased prevalence of coronary heart disease, hypertension, cancer, diabetes, obesity, rheumatoid arthritis, and autoimmune or neurodegenerative disorders. The low intake of ω-3 fatty acids may be attributed to their absence from the diet or lack of awareness about suitable dietary sources.

Key findings and conclusionsA sustainable and cost-effective way of reaching a large population with essential ω-3 fatty acids is fortification of staple foods. A variety of food items enriched with ω-3 have entered the market in recent years, including beef, fish, dairy products, cereals, cereal bars, and infant formula. The present review discusses the role of ω-3 and ω-6 fatty acids, as well as their ratio, on human health. Additionally, it focuses on the latest developments regarding dietary sources, innovative technologies, and challenges of food fortification with ω-3 fatty acids.