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Investigations on the role of ionic liquid on the physicochemical characteristics and toxicological consequences of liposomes
Department of Chemistry, Vidyasagar University, Midnapore, 721102, West Bengal, India.ORCID iD: 0000-0002-4068-4190
Department of Chemistry, Vidyasagar University, Midnapore, 721102, West Bengal, India.ORCID iD: 0000-0001-6187-8990
Department of Chemistry, Vidyasagar University, Midnapore, 721102, West Bengal, India.
Department of Chemistry, Vidyasagar University, Midnapore, 721102, West Bengal, India.
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2022 (English)In: JCIS Open, ISSN 2666-934X, Vol. 6, article id 100050Article in journal (Refereed) Published
Abstract [en]

Effect of 1-butyl-3-methylimidazolium chloride ionic liquid ([bmim]Cl, IL) on the monolayer/bilayer of either soy-phosphatidylcholine (SPC) or hydrogenated soy-phosphatidylcholine (HSPC), in combination with 30 ​mol% cholesterol (Chol), were investigated. Impact of IL on monolayers were explored by measuring the surface pressure (π)-area (A) isotherm with a Langmuir-surface balance. Lift-off area (A0) of the monomolecular films gradually increased [A0(HSPC+IL) ​> ​A0(SPC+IL)], collapse pressures (πc) decreased and passed through minima [πc(HSPC+IL) ​> ​πc(SPC+IL)] with increasing IL concentration ([IL]). Minimum molecular area (Amin) increased monotonously and compression moduli (Cs−1) followed the sequence (HSPC+IL) ​> ​(SPC+IL) at a particular π with respect to [IL]. Dynamic light scattering studies were carried out to determine the hydrodynamic diameter (dh), zeta potential (Z.P.) and polydispersity index (PDI) values while fluorescence anisotropy studies, using 7-hydroxycoumarin and 1,6-diphenyl-1,3,5-hexatriene, could reveal the micro-viscosity of liposomes. Increased size and rigidity, induced by IL, suggest the formation of leak-proof, condensed liposomes. Disruption of vesicles induced by IL were observed from transmission electron microscopic (TEM) studies. IL induced disintegration of liposome and kinetics of subsequent formation of adsorbed monolayer were accomplished by surface pressure-time isotherms. IL-induced liposomes were substantially less toxic as revealed by MTT assay. These liposomes are considered to be safely used as effective and controlled drug delivery systems.

Place, publisher, year, edition, pages
Elsevier, 2022. Vol. 6, article id 100050
Keywords [en]
Ionic liquid, Surface pressure, Monolayers, Vesicles, TEM, Cytotoxicity
National Category
Physical Chemistry Pharmaceutical Sciences
Research subject
Chemistry of Interfaces
Identifiers
URN: urn:nbn:se:ltu:diva-90486DOI: 10.1016/j.jciso.2022.100050Scopus ID: 2-s2.0-85129705123OAI: oai:DiVA.org:ltu-90486DiVA, id: diva2:1655238
Note

Godkänd;2022;Nivå 0;2022-06-02 (hanlid);

Funder: Council of Scientific and Industrial Research (CSIR), Govt. of India (01(2864)/16/EMR-II); Department of Science and Technology (DST) Govt. of India (SR/FST/CS-I/2017/7 (G))

Available from: 2022-05-02 Created: 2022-05-02 Last updated: 2022-06-02Bibliographically approved

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Patra, Anuttam

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