Mathematical models are essential for the development of schedules for the air-circulation drying of timber in Swedish sawmills, but earlier models have been shown to be conservative leading to longer drying times than necessary. In the current study, macroscopic (macro) X-ray computed tomography (CT) has been used in both the development and validation of a finite element (FE) model, to enable the macro-CT aided FE modelling of the nonlinear transient moisture flow in wood. The model uses more advanced theory than has previously been used in Swedish sawmills, by incorporating a surface emission coefficient to simulate the surface resistance to moisture flow. A single piece of Norway spruce [Picea abies (L.) Karst.] timber was subjected to that part of a traditional kiln-drying schedule, which is associated with diffusion-driven moisture transport. The incorporation of macro-CT data into the FE model resulted in a more realistic representation of the board’s geometry, the initial moisture state, and the definition of material parameters. It also led to a better simulation of flow speed and moisture gradient, especially the asymmetric MC development within the cross section throughout the drying process.