The current awareness in unmanned aerial vehicles (UAVs) has prompted not only military applications but also civilian uses. Aerial vehicles’ requirements aspire to guarantee a higher level of safety comparable to see-and-avoid conditions for piloted aeroplanes. The process of probing obstacles in the path of a vehicle and determining whether they pose a threat, alongside measures to avoid these issues, is known as see and avoid or sense and avoid. Other types of decision-making tasks can be accomplished using computer vision and sensor integration since they have a great potential to improve the performance of the UAVs. Macroscopically, UAVs are cyber-physical systems (CPSs) that can benefit from all types of sensing frameworks, despite severe design constraints, such as precision, reliable communication, distributed processing capabilities and data management. This book is paying attention to several issues that are still under discussions in the field of UAV-CPSs. Thus, several trends and needs are discussed to foster criticism from the readers and to provide further food for thought.