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A tale of exosomes and their implication in cancer
Department of Biophysics, All India Institute of Medical Sciences, New Delhi 110029, India.
Department of Biophysics, All India Institute of Medical Sciences, New Delhi 110029, India.
Department of Anatomy, All India Institute of Medical Sciences, New Delhi 110029, India.
Luleå University of Technology, Department of Health, Learning and Technology, Nursing and Medical Technology.
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2023 (English)In: Biochimica et Biophysica Acta - Reviews on Cancer, ISSN 0304-419X, Vol. 1878, no 4, article id 188908Article, review/survey (Refereed) Published
Abstract [en]

Cancer is a cause of high deaths worldwide and also a huge burden for the health system. Cancer cells have unique properties such as a high rate of proliferation, self-renewal, metastasis, and treatment resistance, therefore, the development of novel diagnoses of cancers is a tedious task. Exosomes are secreted by virtually all cell types and have the ability to carry a multitude of biomolecules crucial for intercellular communication, hence, contributing a crucial part in the onset and spread of cancer. These exosomal components can be utilized in the development of markers for diagnostic and prognostic purposes for various cancers. This review emphasized primarily the following topics: exosomes structure and functions, isolation and characterization strategies of exosomes, the role of exosomal contents in cancer with a focus in particular on noncoding RNA and protein, exosomes, and the cancer microenvironment interactions, cancer stem cells, and tumor diagnosis and prognosis based on exosomes.

Place, publisher, year, edition, pages
Elsevier, 2023. Vol. 1878, no 4, article id 188908
Keywords [en]
Exosomes, Exosomes isolation and characterization, cancer pathophysiology, Exosomal proteins, Exosomal miRNA, Cancer Diagnosis
National Category
Cancer and Oncology
Research subject
Biomedical Engineering
Identifiers
URN: urn:nbn:se:ltu:diva-97631DOI: 10.1016/j.bbcan.2023.188908ISI: 001053145600001PubMedID: 37172650Scopus ID: 2-s2.0-85159173747OAI: oai:DiVA.org:ltu-97631DiVA, id: diva2:1760159
Note

Validerad;2023;Nivå 2;2023-05-29 (joosat);

Funder: Indian Council of Medical Research (ICMR); Department of Health Research (DHR); Ministry of Health and Family Welfare

Available from: 2023-05-29 Created: 2023-05-29 Last updated: 2024-03-07Bibliographically approved

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Nikolajeff, FredrikKumar, Saroj

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