Global transportation demand has grown significantly because of rising urbanization and industrialization, together with a concentration of automobiles. The transportation industry's reliance on fossil fuels has increased concerns about sustainability and the environment. On the other side, climate change, global warming, and rising fuel prices have compelled us to seek alternative fuel production technologies in a sustainable manner. The development of renewable and low-carbon energy sources has gained momentum in response to growing petroleum shortages and the effects of greenhouse gas emissions on the planet. Hydrogen (H2)-blended methane (CH4)/compressed natural gas (CNG), which mimics hythane is emerging as an energy carrier for combustion engines due to its cost efficiency and energy reductions. Compared to methane, hythane can lower the emissions of carbon monoxide (CO) and oxides of nitrogen (NOx) up to 30% and 50% respectively. With economic and environmental benefits, hythane is expected to take a long journey, since the blend is in direct use with the existing vehicle engines and has been commercialized as vehicle fuel. Currently CNG is being enriched with H2 (H-CNG) to enhance combustion efficiency. Biogenic waste transformation to H-CNG as fuel has proven to be an emerging solution to enable this goal. Acidogenic fermentation coupled with anaerobic digestion can be a potential technology for the production of hydrogen and methane towards bioH2-CNG/biohythane production from biogenic waste/wastewater as feedstock. This chapter aims to provide an updated overview of the recent advances in biohythane/bioH2-CNG production and usage as fuel.