Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Lung Function Trajectories and Associated Mortality Among Adults with and without Airway Obstruction
Umeå University, Public Health and Clinical Medicine, Occupational and Environmental Medicine/The OLIN unit, Luleå, Sweden.ORCID iD: 0000-0002-0553-8067
Umeå University, 8075, Dept. of Public Health and Clinical Medicine, Umeå, Sweden.ORCID iD: 0000-0002-2452-7347
Umeå Universitet, 8075, Umeå, Sweden.
Luleå University of Technology, Department of Health, Learning and Technology, Health, Medicine and Rehabilitation.ORCID iD: 0000-0002-5948-6880
Show others and affiliations
2023 (English)In: American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, E-ISSN 1535-4970Article in journal (Refereed) Epub ahead of print
Abstract [en]

Rationale: Spirometry is essential for diagnosis and assessment of prognosis in COPD. Objectives: To identify FEV1 trajectories and their determinants, based on annual spirometry measurements among individuals with and without airway obstruction. Furthermore, to assess mortality in relation to trajectories. Methods: In 2002-04, individuals with airway obstruction (AO) (FEV1/VC<0.70, n=993) and age- and sex-matched non-obstructive (NO) referents were recruited from population-based cohorts. Annual spirometries until 2014 were utilized in joint-survival Latent Class Mixed Models to identify lung function trajectories. Mortality data were collected during 15 years of follow-up. Results: Three trajectories were identified among the AO-cases and two among the NO referents. Trajectory membership was driven by baseline FEV1%predicted (%pred) in both groups and additionaly, pack-years in AO and current smoking in NO. Longitudinal FEV1%pred level depended on baseline FEV1%pred, pack-years and obesity. The trajectories were distributed: 79.6% T1AO FEV1-high with normal decline, 12.8% T2AO FEV1-high with rapid decline, and 7.7% T3AO FEV1-low with normal decline (mean 27, 72 and 26 mL/year) among AO-individuals, and 96.7% T1NO FEV1-high with normal decline and 3.3% T2NO FEV1-high with rapid decline (mean 34 and 173 mL/year) among referents. Hazard for death was increased for T2AO (HR1.56) and T3AO (HR3.45) vs. T1AO, and for T2NO (HR2.99) vs. T1NO. Conclusions: Three different FEV1 trajectories were identified among those with airway obstruction and two among the referents, with different outcomes in terms of FEV1-decline and mortality. The FEV1 trajectories among airway obstructive and the relationship between low FVC and trajectory outcome are of particular clinical interest.

Place, publisher, year, edition, pages
ATS journals , 2023.
Keywords [en]
Prognosis, COPD, FEV1, Natural history
National Category
Respiratory Medicine and Allergy
Research subject
Physiotherapy
Identifiers
URN: urn:nbn:se:ltu:diva-100276DOI: 10.1164/rccm.202211-2166ocPubMedID: 37460250OAI: oai:DiVA.org:ltu-100276DiVA, id: diva2:1788235
Available from: 2023-08-16 Created: 2023-08-16 Last updated: 2023-08-16

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records

Strandkvist, Viktor

Search in DiVA

By author/editor
Backman, HelenaBlomberg, AndersStrandkvist, ViktorNilsson, UlfHedman, LinneaStridsman, CarolineLindberg, Anne
By organisation
Health, Medicine and Rehabilitation
In the same journal
American Journal of Respiratory and Critical Care Medicine
Respiratory Medicine and Allergy

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 26 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf