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Retention model for the resolved enantiomers of felodipine on chiral-AGP using micellar mobile phases
Department of Analytical Pharmaceutical Chemistry, Uppsala University, Biomedical Centre, Uppsala, Sweden.
Department of Analytical Pharmaceutical Chemistry, Uppsala University, Biomedical Centre, Uppsala, Sweden.
Department of Analytical Pharmaceutical Chemistry, Uppsala University, Biomedical Centre, Uppsala, Sweden.
1995 (English)In: Chirality, ISSN 0899-0042, E-ISSN 1520-636X, Vol. 7, no 1, p. 23-27Article in journal (Refereed) Published
Abstract [en]

A retention model for the chiral separation of an uncharged solute, felodipine, on CHIRAL-AGP, using a micellar mobile phase is proposed. The model assumes the presence of two stereoselective sites and each enantiomer was found to interact with different sites. Addition of a chiral aliphatic alcohol, (+)-(S)-2-octanol, preferentially interacted with the binding site for (-)-(S)-felodipine. The monomeric form of the micellar agent (Tween® 20) competed with the enantiomers for the adsorption sites, and the formation of a 1:1 complex between the enantiomers and the micelles was assumed. The retention of the solutes was effectively controlled by adding small quantities (

Place, publisher, year, edition, pages
1995. Vol. 7, no 1, p. 23-27
Identifiers
URN: urn:nbn:se:ltu:diva-2619DOI: 10.1002/chir.530070105ISI: A1995QH38300004Scopus ID: 2-s2.0-0028904625Local ID: 042982e0-ec49-11dd-99cd-000ea68e967bOAI: oai:DiVA.org:ltu-2619DiVA, id: diva2:975472
Note

Godkänd; 1995; 20090127 (andbra)

Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2023-05-08Bibliographically approved

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