Weathering of till in northern Sweden results in the formation of well-developed spodosols. The till is dominated by 1.9–1.8 Ga granitic material. The REE are among the elements most strongly depleted during weathering, and the loss of REE from the E-horizon decreases as the atomic number increases. To study if weathering leads to a change of the Nd isotope composition, we have analysed the Nd isotopic composition of the various horizons including living plants and humus of two profiles of weathered till (typic haplocryods) in northern Sweden. As much as between 65.6 and 75.3% of the Sm and Nd in the <0.2 mm fraction has been lost from the E-horizon, and between 32.5 and 54.7% from the B-horizon. Nd has been lost to a slightly greater extent than Sm. The two C-horizon samples have εNd(0) values of −22.1 and −23.2. Corresponding E-horizon values are −18.1 and −20.2. The B-horizon values are intermediate between the values of the E and C horizons. It is concluded that the weathering leads to a change in the Sm/Nd ratio resulting in a change of the Sm-Nd isotope composition. The plant and humus samples deviate even more from the unweathered till. For one station the results could be interpreted as if the Sm and Nd taken up by the plants had similar isotope characteristics as the amounts of these elements released by weathering in the E-horizon. For the other station it is probable that the Nd isotope composition of the organic samples is dominated by Nd released by till weathering which, however, is mixed with another Nd-source, possibly an airborne component. The explanation to the change of isotope compostion in the till is that a larger proportion of the Nd released by weathering is released from minerals with a lower Sm/Nd ratio than the bulk soil, compared with the amount released from minerals with a higher Sm/Nd ratio. Although the various REE-carrying minerals had the same initial Nd isotopic composition, 1.8–1.9 Ga of decay of 147Sm to 143Nd has resulted in a higher present 143Nd/144Nd ratio in the minerals with a higher Sm/Nd ratio.