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Solution structures of Alzheimer’s amyloid Aβ13-23 peptide: NMR studies in solution and in SDS
Kazan (Volga Region) Federal University, Kazan.
Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Sustainable Process Engineering.ORCID iD: 0000-0002-6810-1882
Kazan (Volga Region) Federal University, Kazan.
Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Sustainable Process Engineering.ORCID iD: 0000-0003-1067-7990
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2013 (English)In: Journal of Molecular Structure, ISSN 0022-2860, E-ISSN 1872-8014, Vol. 1049, p. 436-440Article in journal (Refereed) Published
Abstract [en]

To be believed that interaction of amyloid peptides with the cellular membrane is one of the mechanisms for the neurotoxicity of Aβ. Therefore, structural studies of beta-amyloid in solution and in a “peptide - bio-membrane” complex are of intense interest. The aim of this study was to acquire a better understanding of the mechanism of “Aβ peptide-micelle surface” complex formation. Previous studies of Aβ peptides binding on the micelle surface show the presence of helical region between 15-24 residues and that fragment between 11-28 residues have a tendency to exit the hydrophobic environment of the micelle core and to bind to the micelle surface. In present paper we considered the fragment of Aβ from 13 to 23 residues and found that L17, F19 and F20 residues region play a great role in the process of binding of Aβ to the micelle surface.

Place, publisher, year, edition, pages
2013. Vol. 1049, p. 436-440
National Category
Physical Chemistry
Research subject
Chemistry of Interfaces
Identifiers
URN: urn:nbn:se:ltu:diva-3215DOI: 10.1016/j.molstruc.2013.06.043ISI: 000324784700054Scopus ID: 2-s2.0-84885134570Local ID: 1038a1b9-aa80-420e-891f-cd34829441d7OAI: oai:DiVA.org:ltu-3215DiVA, id: diva2:976071
Note
Validerad; 2013; 20130626 (andbra)Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2018-07-10Bibliographically approved

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Filippov, AndreiAntzutkin, Oleg

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