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The expression of androgen receptors in human neck and limb muscles: effects of training and self-administration of androgenic-anabolic steroids
Umeå University, Department of Integrative Medical Biology.
Umeå University, Department of Integrative Medical Biology.
2000 (English)In: Histochemistry and Cell Biology, ISSN 0948-6143, E-ISSN 1432-119X, Vol. 113, no 1, p. 25-9Article in journal (Refereed) Published
Abstract [en]

The purpose of this study was to investigate the immunohistochemical expression of androgen receptors (AR) in human vastus lateralis and trapezius muscles and to determine whether long-term strength training and self-administration of androgenic-anabolic steroids are accompanied by changes in AR content. Biopsy samples were taken from eight high-level power-lifters (P), nine high-level power-lifters who used anabolic steroids (PAS) and six untrained subjects (U). Myonuclei and AR were visualised in cross-sections stained with the monoclonal antibody against AR and 4',6-diamidino-2-phenylindole. The proportion of AR-containing myonuclei per fibre cross-section was higher in the trapezius than in the vastus lateralis (P<0.05). In the trapezius, the proportion of AR-containing myonuclei was higher in P compared to U and in PAS compared to both P and U (P<0. 05). On the contrary, in the vastus lateralis, there were no differences in AR content between the three groups. Myonuclear number in both muscles was higher in P compared to U and in PAS compared to both P and U (P<0.05). In conclusion, AR content differs greatly between human neck and limb muscles. Moreover, the regulation of AR-containing myonuclei following training and self-administration of androgenic-anabolic steroids is muscle dependent.

Place, publisher, year, edition, pages
2000. Vol. 113, no 1, p. 25-9
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URN: urn:nbn:se:ltu:diva-3518DOI: 10.1007/s004180050003Local ID: 1584dfe0-e1c8-11db-b0f8-000ea68e967bOAI: oai:DiVA.org:ltu-3518DiVA, id: diva2:976376
Note
Upprättat; 2000; 20070403 (andbra)Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2017-11-24Bibliographically approved

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