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Measurement of iron and zinc isotopes in human whole blood: preliminary application to the study of HFE genotypes
Luleå tekniska universitet.
Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Geosciences and Environmental Engineering.
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2005 (English)In: Journal of Trace Elements in Medicine and Biology, ISSN 0946-672X, E-ISSN 1878-3252, Vol. 19, no 1, p. 55-60Article in journal (Refereed) Published
Abstract [en]

Multi-collector inductively coupled plasma - sector field mass spectrometry was applied to the measurement of Fe and Zn isotopes in human whole blood samples. For the Fe present in the blood of healthy adults, enrichment of the lighter isotopes relative to a standard material was observed, in agreement with earlier studies. The level of fractionation was found to be lower in hemochromatosis patients exhibiting homozygous (C282Y/C282Y) mutation of the HFE gene. On the one hand, this reinforces the hypothesis that Fe fractionation in blood decreases with enhanced dietary absorption. On the other hand, this contradicts predictions made on the basis of determinations of Fe fractionation in blood samples collected from subjects characterized by milder HFE mutations. In healthy subjects, the Zn in blood is depleted in lighter isotopes, consistent with the limited number of prior observations. As for Fe, the Zn isotopic composition exhibited a tendency toward lower levels of fractionation in the blood of subjects with hereditary hemochromatosis with homozygous mutation (C282Y/C282Y) of the HFE gene. The results therefore suggest that both Fe and Zn isotopic signatures in whole blood, at least to some extent, reflect polymorphisms in the HFE gene.

Place, publisher, year, edition, pages
2005. Vol. 19, no 1, p. 55-60
National Category
Bioprocess Technology Geochemistry
Research subject
Biochemical Process Engineering; Applied Geology
Identifiers
URN: urn:nbn:se:ltu:diva-3632DOI: 10.1016/j.jtemb.2005.07.004Local ID: 1738bcf0-0610-11dc-b09b-000ea68e967bOAI: oai:DiVA.org:ltu-3632DiVA: diva2:976490
Note
Validerad; 2005; Bibliografisk uppgift: SECOND INTERNATIONAL FESTEM SYMPOSIUM; 20070519 (ysko)Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2017-11-24Bibliographically approved

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Malinovskiy, DmitryÖhlander, BjörnAndren, HenrikForsling, WillisEngström, EmmaRodushkin, IlyaBaxter, Douglas
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