Entrepreneurship as a domain of research has grown by benefiting from more established disciplines. However, a commonality in the early stages of applying established theories to entrepreneurship is the lack of grounded research frameworks. This paper reviews literature on role stress and develops a conceptual framework that illustrates how this construct can serve entrepreneurship research. Based on a review of psychological and sociological literature, the paper proposes a model of antecedents and consequences to entrepreneur role stress. Suggestions for future research and practical implications are also presented